Solanum melongena L. (Solanaceae) is an important species both nutritionally and economically. Having a better knowledge of the effects of heterosis could help to improve the characteristics of eggplant crops. The aim of the study was to identify interspecific hybrids with agromorphological characteristics superior to those of their parents, as well as the parental accessions that produced the best interspecific hybrid combinations. 15 agromorphological parameters were used to characterize eight accessions of S. melongena, eight accessions from the primary and secondary gene pools species and 36 interspecific hybrid progenies obtained between S. melongena and species from different gene pools. The results showed that heterosis effects were more important for vegetative growth characteristics than for production. The M4 × IS3 interspecific hybrid was the best in terms of heterosis effects for both vegetative growth and production characteristics. The parental accessions IS3 from the primary gene pool and DS1 from the secondary pool gave hybrids with the greatest heterosis effects. The phenotypic characteristics of the parental accessions and the heterosis effects of hybrids offer interesting prospects for eggplant breeding by introgression of genes from wild species in the cultivated species S. melongena.